Mechanism and Prevention of Titanium Particle-Induced Inflammation and Osteolysis

“Here we show that a strong inflammatory response occurs; however, very few of the titanium particles are phagocytosed by the macrophages. We then measured a dramatic Ti particle-induced stimulation of IL1β, IL6, and TNFα secretion by these macrophages using multiplex immunoassay. The particle-induced expression profile, examined by FACS, also indicated an M1 macrophage polarization.”

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Implant Tribune

Spotlight on ZERAMEX®XT for the month of April 2020