Tag Archives: Titanium and Peri-Implantitis

Zeramex Company Blog

Free Radical Production, Inflammation and Apoptosis in Patients Treated With Titanium Mandibular Fixations—An Observational Study

Despite high biocompatibility of titanium and its alloys, this metal causes various side effects in the human body. It is believed that titanium biomaterials may induce an innate/adaptive immune response. However, still little is known about changes caused by titanium mandible implants, particularly with regard to bone healing.

Side Effects of Dental Metal Implants: Impact on Human Health (Metal as a Risk Factor of Implantologic Treatment)

Dental implants are often made of titanium alloys. Implant therapy currently promises a good long-term result without impacting health; however, its success depends on many factors. In this article, the authors focus on the most common risk factors associated with metallic surgical implants.

Evaluation of the biological effect of Ti generated debris from metal implants: ions and nanoparticles

Metallic implants placed in humans exhibit wear and corrosion that result in the liberation of metal-containing by-products. In the case of titanium (Ti) containing implants, the metal containing debris may exist in a number of states, including metallic particles produced by mechanical wear and the products of metal corrosion in biological environments, such as the joints and surrounding fluids and tissues.

Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels

Titanium implants are routinely used for bone fractures as well as dental work. It has recently been shown that titanium-based implants both corrode and degrade, generating metallic debris. There is some concern over the increased concentrations of circulating metal-degradation products derived from these implants, and their potential harmful biological effects over a period of time, including hepatic injury and renal lesions.

Titanium Exposure and Human Health

This review is based on current titanium research demonstrating the many factors that can pose a negative impact on human health when exposed to the various forms of titanium, including its relationship and interactions with other metals.

Titanium is a highly thrombogenic biomaterial: possible implications for osteogenesis

This study indicates that titanium is unsuitable as a biomaterial in devices which are in direct contact with blood for a prolonged period.

Cytokine pathways in the implant area during osseointegration from TNF-α to RANTES/CCL5 overexpression with longterm, negative immune response, and effects

Ischaemic hypoxic medullary bone occurs when there is a disruption in the vascular supply of that bone tissue. Such disruption can occur when a thrombus (clot) is formed and does not subsequently break down (fibrinolysis).

Titanium implants and silent inflammation in jawbone—a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?

All DTI (Dental Titanium Implant)-FDOJ (Fatty Degeneration with Osteonecrosis of the Jaw) samples showed RANTES/CCL5 (R/C) as the only extremely overexpressed cytokine. DTI-FDOJ cohort showed a 30-fold mean overexpression of R/C as compared with a control cohort of 19 healthy JB samples.

Pathogenesis of peri-implantitis

Peri-implantitis is a pathogenetically complex clinical picture and, in addition to local effects, has systemic effects depending on individual genetic susceptibility. It has some similarities to periodontitis but differs in the taxonomic biofilm composition and is also involved in foreign body reactions to the implant material.

Implant Tribune

Spotlight on ZERAMEX®XT for the month of April 2020