Biological reaction to alumina, zirconia, titanium and polyethylene particles implanted onto murine calvaria

The inflammatory response and bone resorption induced by ceramic particles were much smaller than those induced by polyethylene and Ti6Al4V. These biological features suggest the biocompatibility of ceramics as a joint surface material for artificial joints.

Note from the webmaster:  it should be noted that the release of zirconia particles from a ceramic implant will be significantly less than a titanium implant since zirconia is much more stable and resistant to corrosion than titanium in the oral environment.