The effect of metal ions released from different dental implant-abutment couples on osteoblast function and secretion of bone resorbing mediators

Bone Resorbing Mediators


Metal ions in concentrations representing the platform-matched groups led to a reduction in cell viability (P<0.01) up to 7days of exposure. Stimulated cells showed higher rates of early apoptosis (P<0.01) compared to non-treated cells. Metal ions up-regulated the expression of interleukin-6, interleukin-8, cyclooxygenase-2 and RANKL in a dose dependent manner after 1day of exposure (P<0.05). The up-regulation was more pronounced in the groups containing the corrosion products of platform-matched implant-abutment couples.


Osteoblastic cell viability, apoptosis, and regulation of bone resorbing mediators were significantly altered in the presence of metal ions. The change in cytokine levels expressed was directly proportional to the metal ion concentration.

Leave a Reply

Your email address will not be published. Required fields are marked *

Implant Tribune

Spotlight on ZERAMEX®XT for the month of April 2020