Zeramex Company Blog

Cytokine pathways in the implant area during osseointegration from TNF-α to RANTES/CCL5 overexpression with longterm, negative immune response, and effects

Ischaemic hypoxic medullary bone occurs when there is a disruption in the vascular supply of that bone tissue. Such disruption can occur when a thrombus (clot) is formed and does not subsequently break down (fibrinolysis).

Titanium implants and silent inflammation in jawbone—a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?

All DTI (Dental Titanium Implant)-FDOJ (Fatty Degeneration with Osteonecrosis of the Jaw) samples showed RANTES/CCL5 (R/C) as the only extremely overexpressed cytokine. DTI-FDOJ cohort showed a 30-fold mean overexpression of R/C as compared with a control cohort of 19 healthy JB samples.

Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model

Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model.

Titanium particles/ions detected in peri-implant tissues have been considered as a potential etiologic factor for crestal bone loss around oral implants. However, the definite impact of titanium wear particles on the health of surrounding structures remains undetermined.

Pathogenesis of peri-implantitis

Peri-implantitis is a pathogenetically complex clinical picture and, in addition to local effects, has systemic effects depending on individual genetic susceptibility. It has some similarities to periodontitis but differs in the taxonomic biofilm composition and is also involved in foreign body reactions to the implant material.

Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss

Metal Nanoparticles Released from Dental Implant

The aim of this study is to identify the role of titanium nanoparticles released form the implants on the chronic inflammation and bone lysis in the surrounding tissue.

Association of Global DNA Methylation to Titanium and Peri-Implantitis: A Case-Control Study

Association of Global DNA Methylation

Epigenetic changes are associated with various inflammatory diseases and are influenced by environmental factors. Recent data support an association between titanium dissolution products and peri-implantitis.

Polymorphisms, Bone Health & Peri-implantitis

Other relevant polymorphisms adversely impacting on bone health can increase the risk of peri-implantitis by affecting the rate of bone turnover, the bone mineral density and the formation of the collagen based bone matrix.

Potential Causes of Titanium Particle and Ion Release in Implant Dentistry: A Systematic Review

Potential Causes of Titanium Particle and Ion Release

Implant surface characteristics, as well as physical and mechanical properties, are responsible for the positive interaction between the dental implant, the bone and the surrounding soft tissues.

Can degradation products released from dental implants affect peri-implant tissues?

Dental implants affect peri-implant tissues

Degenerative changes were reported in macrophages and neutrophils that phagocytosed titanium microparticles, and mutations occurred in human cells cultured in medium containing titanium-based nanoparticles.

Implant Tribune

Spotlight on ZERAMEX®XT for the month of April 2020